SCOPe 2.03: Domain d3zlsa_: 3zls A:

Lineage for d3zlsa_ (3zls A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (11 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (418 PDB entries)

8. Domain d3zlsa_: 3zls A: [218317]
   automated match to d1s9ia_
   complexed with 92p, na

Details for d3zlsa_

PDB Entry: 3zls, 2.5 Å

PDB Description: Crystal structure of MEK1 in complex with fragment 6

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d3zlsa_:

Sequence, based on SEQRES records:

>d3zlsa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkl
ihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkka
gripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlids
mansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcq
vegdaaetpprprtpgrplnkkgmdsrppmaifelldyivnepppklpsgvfslefqdfv
nkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigln

Sequence, based on observed residues (ATOM records):

>d3zlsa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkl
ihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkka
gripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlids
mansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcp
maifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdae
evdfagwlcstigln

Timeline for d3zlsa_:

• d3zlsa_ is new in SCOPe 2.03-stable
  
• d3zlsa_ appears in SCOPe 2.04
  
• d3zlsa_ appears in the current release, SCOPe 2.08