SCOPe 2.08: Domain d3vw8a_: 3vw8 A:

Lineage for d3vw8a_ (3vw8 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (67 PDB entries)

8. Domain d3vw8a_: 3vw8 A: [218124]
   automated match to d3u6ha_
   complexed with cl, df6

Details for d3vw8a_

PDB Entry: 3vw8, 2.1 Å

PDB Description: crystal structure of human c-met kinase domain with its inhibitor

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d3vw8a_:

Sequence, based on SEQRES records:

>d3vw8a_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
vqypltdmspiltsgdsdisspllqntvhidlslnpelvqavqhvvigpsslivhfnevi
grghfgcvyhgtlldndgkkihcavkslnritdigevsqfltegiimkdfshpnvlsllg
iclrsegsplvvlpymkhgdlrnfirnethnptvkdligfglqvakgmkylaskkfvhrd
laarncmldekftvkvadfglardmydkeyysvhnktgaklpvkwmaleslqtqkfttks
dvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdplyevmlkcwhpka
emrpsfselvsrisaifstfigehyvhv

Sequence, based on observed residues (ATOM records):

>d3vw8a_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
vqypltdmspiltsgddlslnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtll
dndgkkihcavkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlp
ymkhgdlrnfirnethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftv
kvadfglardmydkeyysaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappy
pditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehy
vhv

Timeline for d3vw8a_:

• d3vw8a_ first appeared in SCOPe 2.03
  
• d3vw8a_ appears in SCOPe 2.07