SCOPe 2.03: Domain d3vs6a1: 3vs6 A:85-146

Lineage for d3vs6a1 (3vs6 A:85-146)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.34: SH3-like barrel [50036] (21 superfamilies)
   barrel, partly opened; n*=4, S*=8; meander
   the last strand is interrupted by a turn of 3-10 helix

4. Superfamily b.34.2: SH3-domain [50044] (2 families)

5. Family b.34.2.1: SH3-domain [50045] (40 proteins)

6. Protein Hemapoetic cell kinase Hck [50062] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50063] (20 PDB entries)

8. Domain d3vs6a1: 3vs6 A:85-146 [218094]
   Other proteins in same PDB: d3vs6a2, d3vs6a3, d3vs6b2, d3vs6b3
   automated match to d1qcfa1
   complexed with ca, cl, vsh

Details for d3vs6a1

PDB Entry: 3vs6, 2.37 Å

PDB Description: Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor tert-butyl {4-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate

PDB Compounds: (A:) Tyrosine-protein kinase HCK

SCOPe Domain Sequences for d3vs6a1:

Sequence; same for both SEQRES and ATOM records:

>d3vs6a1 b.34.2.1 (A:85-146) Hemapoetic cell kinase Hck {Human (Homo sapiens) [TaxId: 9606]}
riivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsnyvarvdsl
et

Timeline for d3vs6a1:

• d3vs6a1 is new in SCOPe 2.03-stable
  
• d3vs6a1 appears in SCOPe 2.04
  
• d3vs6a1 appears in the current release, SCOPe 2.08