SCOPe 2.03: Domain d3vs2a2: 3vs2 A:147-249

Lineage for d3vs2a2 (3vs2 A:147-249)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.1: SH2 domain [55551] (35 proteins)
   Pfam PF00017

6. Protein Hemopoetic cell kinase Hck [55565] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55566] (17 PDB entries)

8. Domain d3vs2a2: 3vs2 A:147-249 [218071]
   Other proteins in same PDB: d3vs2a1, d3vs2a3, d3vs2b1, d3vs2b3
   automated match to d1qcfa2
   complexed with ca, cl, vsb

Details for d3vs2a2

PDB Entry: 3vs2, 2.61 Å

PDB Description: Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

PDB Compounds: (A:) Tyrosine-protein kinase HCK

SCOPe Domain Sequences for d3vs2a2:

Sequence, based on SEQRES records:

>d3vs2a2 d.93.1.1 (A:147-249) Hemopoetic cell kinase Hck {Human (Homo sapiens) [TaxId: 9606]}
eewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvkhykir
tldnggfyisprstfstlqelvdhykkgndglcqklsvpcmss

Sequence, based on observed residues (ATOM records):

>d3vs2a2 d.93.1.1 (A:147-249) Hemopoetic cell kinase Hck {Human (Homo sapiens) [TaxId: 9606]}
eewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvkhykir
tlgfyisprstfstlqelvdhykkgndglcqklsvpcmss

Timeline for d3vs2a2:

• d3vs2a2 is new in SCOPe 2.03-stable
  
• d3vs2a2 appears in SCOPe 2.04
  
• d3vs2a2 appears in the current release, SCOPe 2.08