SCOPe 2.08: Domain d3tjpa4: 3tjp A:726-1093

Lineage for d3tjpa4 (3tjp A:726-1093)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (2 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (78 PDB entries)

8. Domain d3tjpa4: 3tjp A:726-1093 [216845]
   Other proteins in same PDB: d3tjpa1, d3tjpa2, d3tjpa3
   automated match to d1e8ya4
   complexed with 13k, so4

Details for d3tjpa4

PDB Entry: 3tjp, 2.7 Å

PDB Description: Crystal Structure of PI3K gamma with N6-(3,4-dimethoxyphenyl)-2-morpholino-[4,5'-bipyrimidine]-2',6-diamine

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3tjpa4:

Sequence, based on SEQRES records:

>d3tjpa4 d.144.1.4 (A:726-1093) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhlvlg

Sequence, based on observed residues (ATOM records):

>d3tjpa4 d.144.1.4 (A:726-1093) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptanetigiifkhgddlrqdmlilqi
lrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevl
nhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfgh
ilgnervpfvltpdflfvmgtsgktsphfqkfqdicvkaylalrhhtnlliilfsmmlmt
gmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlg

Timeline for d3tjpa4:

• d3tjpa4 first appeared in SCOPe 2.03
  
• d3tjpa4 appears in SCOPe 2.07