SCOPe 2.03: Domain d3tfsa3: 3tfs A:149-335

Lineage for d3tfsa3 (3tfs A:149-335)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.218: Nucleotidyltransferase [81302] (1 superfamily)
   core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123

4. Superfamily d.218.1: Nucleotidyltransferase [81301] (15 families)

5. Family d.218.1.2: DNA polymerase beta-like [81300] (4 proteins)
   insert X in the core is an alpha-beta(2) unit; mixed 5-stranded sheet, order: 12543; contains extra C-terminal alpha+beta subdomain

6. Protein DNA polymerase beta, catalytic (31 kD) fragment [81578] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [81574] (132 PDB entries)
   Uniprot P06746

8. Domain d3tfsa3: 3tfs A:149-335 [216800]
   Other proteins in same PDB: d3tfsa1, d3tfsa2
   automated match to d1tv9a3
   protein/DNA complex; complexed with cl, fha, mg, na

Details for d3tfsa3

PDB Entry: 3tfs, 2 Å

PDB Description: Ternary complex structure of DNA polymerase beta with a gapped DNA substrate and a, b dAMP(CFH)PP in the active site: Stereoselective binding of (S) isomer

PDB Compounds: (A:) DNA polymerase beta

SCOPe Domain Sequences for d3tfsa3:

Sequence; same for both SEQRES and ATOM records:

>d3tfsa3 d.218.1.2 (A:149-335) DNA polymerase beta, catalytic (31 kD) fragment {Human (Homo sapiens) [TaxId: 9606]}
ripreemlqmqdivlnevkkvdseyiatvcgsfrrgaessgdmdvllthpsftsestkqp
kllhqvveqlqkvhfitdtlskgetkfmgvcqlpskndekeyphrridirlipkdqyycg
vlyftgsdifnknmrahalekgftineytirplgvtgvageplpvdsekdifdyiqwkyr
epkdrse

Timeline for d3tfsa3:

• d3tfsa3 is new in SCOPe 2.03-stable
  
• d3tfsa3 appears in SCOPe 2.04
  
• d3tfsa3 appears in the current release, SCOPe 2.08