SCOPe 2.06: Domain d3srkb1: 3srk B:0-87,B:187-357

Lineage for d3srkb1 (3srk B:0-87,B:187-357)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.12: Phosphoenolpyruvate/pyruvate domain [51621] (8 families)

5. Family c.1.12.1: Pyruvate kinase [51622] (1 protein)

6. Protein Pyruvate kinase, N-terminal domain [51623] (6 species)
   this domain is interrupted by an all-beta domain
   C-terminal domain is alpha/beta

7. Species Trypanosome (Leishmania mexicana) [TaxId:5665] [51626] (11 PDB entries)

8. Domain d3srkb1: 3srk B:0-87,B:187-357 [216525]
   Other proteins in same PDB: d3srka2, d3srka3, d3srkb2, d3srkb3
   automated match to d1pkla2
   complexed with k, lsa, ptk

Details for d3srkb1

PDB Entry: 3srk, 2.65 Å

PDB Description: A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase

PDB Compounds: (B:) pyruvate kinase

SCOPe Domain Sequences for d3srkb1:

Sequence; same for both SEQRES and ATOM records:

>d3srkb1 c.1.12.1 (B:0-87,B:187-357) Pyruvate kinase, N-terminal domain {Trypanosome (Leishmania mexicana) [TaxId: 5665]}
msqlahnltlsifdpvanyraariictigpstqsvealkgliqsgmsvarmnfshgshey
hqttinnvrqaaaelgvniaialdtkgpXpavsakdrvdlqfgveqgvdmifasfirsae
qvgdvrkalgpkgrdimiickienhqgvqnidsiieesdgimvargdlgveipaekvvva
qkiliskcnvagkpvicatqmlesmtynprptraevsdvanavfngadcvmlsgetakgk
ypnevvqymaricleaqsal

Timeline for d3srkb1:

• d3srkb1 first appeared in SCOPe 2.03
  
• d3srkb1 appears in SCOPe 2.05
  
• d3srkb1 appears in SCOPe 2.07
  
• d3srkb1 appears in the current release, SCOPe 2.08