SCOPe 2.05: Domain d1ce1l2: 1ce1 L:108-211

Lineage for d1ce1l2 (1ce1 L:108-211)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (144 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1ce1l2: 1ce1 L:108-211 [21310]
   Other proteins in same PDB: d1ce1h1, d1ce1h2, d1ce1l1
   part of humanized therapeutic antibody CAMPATH-1H

Details for d1ce1l2

PDB Entry: 1ce1, 1.9 Å

PDB Description: 1.9a structure of the therapeutic antibody campath-1h fab in complex with a synthetic peptide antigen

PDB Compounds: (L:) protein (campath-1h:light chain)

SCOPe Domain Sequences for d1ce1l2:

Sequence; same for both SEQRES and ATOM records:

>d1ce1l2 b.1.1.2 (L:108-211) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnr

Timeline for d1ce1l2:

• d1ce1l2 first appeared (with stable ids) in SCOP 1.55
  
• d1ce1l2 appears in SCOPe 2.04
  
• d1ce1l2 appears in SCOPe 2.06
  
• d1ce1l2 appears in the current release, SCOPe 2.08