SCOPe 2.08: Domain d3kvja_: 3kvj A:

Lineage for d3kvja_ (3kvj A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (8 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (69 PDB entries)

8. Domain d3kvja_: 3kvj A: [212553]
   automated match to d1uuoa_
   complexed with 1x5, act, det, dor, fmn, so4
   has additional subdomain(s) that are not in the common domain
   has additional insertions and/or extensions that are not grouped together

Details for d3kvja_

PDB Entry: 3kvj, 1.94 Å

PDB Description: crystal structure of human dihydroorotate dehydrogenase (dhodh) with amino-benzoic acid inhibitor 105 at 1.94a resolution

PDB Compounds: (A:) Dihydroorotate dehydrogenase, mitochondrial

SCOPe Domain Sequences for d3kvja_:

Sequence, based on SEQRES records:

>d3kvja_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
gderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpv
giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
vsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvv
kelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiig
vggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaiga
dhrr

Sequence, based on observed residues (ATOM records):

>d3kvja_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
gderfyahlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpvg
iaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshg
lsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnv
sspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvk
elgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigv
ggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigad
hrr

Timeline for d3kvja_:

• d3kvja_ first appeared in SCOPe 2.03
  
• d3kvja_ appears in SCOPe 2.07