SCOPe 2.08: Domain d3kqhb2: 3kqh B:326-624

Lineage for d3kqhb2 (3kqh B:326-624)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.14: RNA helicase [52724] (7 proteins)
   duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension

6. Protein HCV helicase domain, C-terminal domain [418963] (1 species)

7. Species Human hepatitis C virus (HCV), different isolates [TaxId:11103] [419425] (15 PDB entries)

8. Domain d3kqhb2: 3kqh B:326-624 [212492]
   Other proteins in same PDB: d3kqha1, d3kqhb1
   automated match to d1heia2
   protein/DNA complex
   has additional subdomain(s) that are not in the common domain

Details for d3kqhb2

PDB Entry: 3kqh, 2.4 Å

PDB Description: three conformational snapshots of the hepatitis c virus ns3 helicase reveal a ratchet translocation mechanism

PDB Compounds: (B:) Serine protease/NTPase/helicase NS3

SCOPe Domain Sequences for d3kqhb2:

Sequence; same for both SEQRES and ATOM records:

>d3kqhb2 c.37.1.14 (B:326-624) HCV helicase domain, C-terminal domain {Human hepatitis C virus (HCV), different isolates [TaxId: 11103]}
pgsvtvphpnieevalsstgeipfygkaipietikggrhlifchskkkcdelaaklsglg
lnavayyrgldvsviptsgdvivvatdalmtgftgdfdsvidcntcvtqtvdfsldptft
ietttvpqdavsrsqrrgrtgrgrmgiyrfvtpgerpsgmfdssvlcecydagcawyelt
paetsvrlraylntpglpvcqdhlefwesvftglthidahflsqtkqagdnfpylvayqa
tvcaraqapppswdqmwkclirlkptlhgptpllyrlgavqnevttthpitkyimacms

Timeline for d3kqhb2:

• d3kqhb2 first appeared in SCOPe 2.03
  
• d3kqhb2 appears in SCOPe 2.07