SCOPe 2.06: Domain d3kktb_: 3kkt B:

Lineage for d3kktb_ (3kkt B:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b [48549] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48550] (30 PDB entries)
   Uniprot Q07343 324-667

8. Domain d3kktb_: 3kkt B: [212405]
   automated match to d1xm6a_
   complexed with 0cp, b3p, mg, zn

Details for d3kktb_

PDB Entry: 3kkt, 2.48 Å

PDB Description: Crystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509.

PDB Compounds: (B:) cAMP-specific 3',5'-cyclic phosphodiesterase 4B

SCOPe Domain Sequences for d3kktb_:

Sequence, based on SEQRES records:

>d3kktb_ a.211.1.2 (B:) Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b {Human (Homo sapiens) [TaxId: 9606]}
srfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfriss
dtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaai
hdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqt
lrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadl
snptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhp
lwetwadlvqpdaqdildtlednrnwyqsmipqspsppldeqnrdcqglmekfqfel

Sequence, based on observed residues (ATOM records):

>d3kktb_ a.211.1.2 (B:) Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b {Human (Homo sapiens) [TaxId: 9606]}
srfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfriss
dtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaai
hdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqt
lrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadl
snptkslelyrqwtdrimeeffqqgdkerergmeispmcdkveksqvgfidyivhplwet
wadlvqpdaqdildtlednrnwyqsmcqglmekfqfel

Timeline for d3kktb_:

• d3kktb_ first appeared in SCOPe 2.03
  
• d3kktb_ appears in SCOPe 2.05
  
• d3kktb_ appears in SCOPe 2.07
  
• d3kktb_ appears in the current release, SCOPe 2.08