SCOPe 2.06: Domain d3is4a3: 3is4 A:358-498

Lineage for d3is4a3 (3is4 A:358-498)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.49: Pyruvate kinase C-terminal domain-like [52934] (2 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145, strand 5 is antiparallel to the rest

4. Superfamily c.49.1: PK C-terminal domain-like [52935] (2 families)

5. Family c.49.1.1: Pyruvate kinase, C-terminal domain [52936] (1 protein)
   automatically mapped to Pfam PF02887

6. Protein Pyruvate kinase, C-terminal domain [52937] (6 species)

7. Species Trypanosome (Leishmania mexicana) [TaxId:5665] [52940] (11 PDB entries)

8. Domain d3is4a3: 3is4 A:358-498 [211865]
   Other proteins in same PDB: d3is4a1, d3is4a2, d3is4b1, d3is4b2
   automated match to d1pkla3
   complexed with gol, ptk

Details for d3is4a3

PDB Entry: 3is4, 2.1 Å

PDB Description: crystal structure of leishmania mexicana pyruvate kinase (lmpyk)in complex with 1,3,6,8-pyrenetetrasulfonic acid

PDB Compounds: (A:) pyruvate kinase

SCOPe Domain Sequences for d3is4a3:

Sequence, based on SEQRES records:

>d3is4a3 c.49.1.1 (A:358-498) Pyruvate kinase, C-terminal domain {Trypanosome (Leishmania mexicana) [TaxId: 5665]}
neyvffnsikklqhipmsadeavcssavnsvyetkakamvvlsntgrsarlvakyrpncp
ivcvttrlqtcrqlnitqgvesvffdadklghdegkehrvaagvefakskgyvqtgdycv
vihadhkvkgyanqtrillve

Sequence, based on observed residues (ATOM records):

>d3is4a3 c.49.1.1 (A:358-498) Pyruvate kinase, C-terminal domain {Trypanosome (Leishmania mexicana) [TaxId: 5665]}
neyvffnsikklqhipmsadeavcssavnsvyetkakamvvlsntgrsarlvakyrpncp
ivcvttrlqtcrqlnitqgvesvffdadklghdegkehrvaagvefakskgyvqtgdycv
vihayanqtrillve

Timeline for d3is4a3:

• d3is4a3 first appeared in SCOPe 2.03
  
• d3is4a3 appears in SCOPe 2.05
  
• d3is4a3 appears in SCOPe 2.07
  
• d3is4a3 appears in the current release, SCOPe 2.08