SCOPe 2.08: Domain d1ucbl2: 1ucb L:109-214

Lineage for d1ucbl2 (1ucb L:109-214)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (147 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1ucbl2: 1ucb L:109-214 [21132]
   Other proteins in same PDB: d1ucbh1, d1ucbh2, d1ucbl1
   part of humanized Fab CBR96
   complexed with so4

Details for d1ucbl2

PDB Entry: 1ucb, 2.5 Å

PDB Description: structure of uncomplexed fab compared to complex (1cly, 1clz)

PDB Compounds: (L:) chimeric human/mouse igg fab fragment br96

SCOPe Domain Sequences for d1ucbl2:

Sequence; same for both SEQRES and ATOM records:

>d1ucbl2 b.1.1.2 (L:109-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds
kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d1ucbl2:

• d1ucbl2 first appeared (with stable ids) in SCOP 1.55
  
• d1ucbl2 appears in SCOPe 2.07