SCOPe 2.01: Domain d1hkll2: 1hkl L:110-214

Lineage for d1hkll2 (1hkl L:110-214)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (5 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (132 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1hkll2: 1hkl L:110-214 [21120]
   Other proteins in same PDB: d1hklh1, d1hklh2, d1hkll1
   part of humanized Fab 48G7

Details for d1hkll2

PDB Entry: 1hkl, 2.68 Å

PDB Description: free and liganded form of an esterolytic catalytic antibody

PDB Compounds: (L:) 48g7 fab

SCOPe Domain Sequences for d1hkll2:

Sequence; same for both SEQRES and ATOM records:

>d1hkll2 b.1.1.2 (L:110-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk
dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d1hkll2:

• d1hkll2 first appeared (with stable ids) in SCOP 1.55
  
• d1hkll2 appears in SCOP 1.75
  
• d1hkll2 appears in SCOPe 2.02
  
• d1hkll2 appears in the current release, SCOPe 2.08