SCOPe 2.08: Domain d1aj7l2: 1aj7 L:110-214

Lineage for d1aj7l2 (1aj7 L:110-214)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (147 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1aj7l2: 1aj7 L:110-214 [21116]
   Other proteins in same PDB: d1aj7h1, d1aj7h2, d1aj7h3, d1aj7l1
   part of humanized Fab 48G7
   complexed with npe

Details for d1aj7l2

PDB Entry: 1aj7, 2.1 Å

PDB Description: immunoglobulin 48g7 germline fab antibody complexed with hapten 5-(para-nitrophenyl phosphonate)-pentanoic acid. affinity maturation of an esterolytic antibody

PDB Compounds: (L:) immunoglobulin 48g7 fab (light chain)

SCOPe Domain Sequences for d1aj7l2:

Sequence; same for both SEQRES and ATOM records:

>d1aj7l2 b.1.1.2 (L:110-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk
dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d1aj7l2:

• d1aj7l2 first appeared (with stable ids) in SCOP 1.55
  
• d1aj7l2 appears in SCOPe 2.07