SCOPe 2.04: Domain d1gafl2: 1gaf L:110-214

Lineage for d1gafl2 (1gaf L:110-214)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (144 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1gafl2: 1gaf L:110-214 [21114]
   Other proteins in same PDB: d1gafh1, d1gafh2, d1gafl1
   part of humanized Fab 48G7
   complexed with npe

Details for d1gafl2

PDB Entry: 1gaf, 1.95 Å

PDB Description: 48g7 hybridoma line fab complexed with hapten 5-(para-nitrophenyl phosphonate)-pentanoic acid

PDB Compounds: (L:) chimeric 48g7 fab

SCOPe Domain Sequences for d1gafl2:

Sequence; same for both SEQRES and ATOM records:

>d1gafl2 b.1.1.2 (L:110-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk
dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d1gafl2:

• d1gafl2 first appeared (with stable ids) in SCOP 1.55
  
• d1gafl2 appears in SCOPe 2.03
  
• d1gafl2 appears in SCOPe 2.05
  
• d1gafl2 appears in the current release, SCOPe 2.08