SCOPe 2.06: Domain d2zkhh1: 2zkh H:1-116

Lineage for d2zkhh1 (2zkh H:1-116)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1 [TaxId:10090] [88548] (68 PDB entries)
   Uniprot P01796 # ! HV27_MOUSE Ig heavy chain V-III region A4

8. Domain d2zkhh1: 2zkh H:1-116 [207868]
   Other proteins in same PDB: d2zkhh2, d2zkhl1, d2zkhl2
   automated match to d1v7mh1

Details for d2zkhh1

PDB Entry: 2zkh, 2.04 Å

PDB Description: human thrombopoietin neutralizing antibody tn1 fab

PDB Compounds: (H:) Monoclonal TN1 Fab Heavy Chain

SCOPe Domain Sequences for d2zkhh1:

Sequence; same for both SEQRES and ATOM records:

>d2zkhh1 b.1.1.1 (H:1-116) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 1 [TaxId: 10090]}
evkleesggglvqpggsmklscaasgftfsdawmdwvrqspekglewvaeirskvnnhai
hyaesvkgrftvsrddskssvylqmnslraedtgiyycsgwsflywgqgtlvtvsa

Timeline for d2zkhh1:

• d2zkhh1 first appeared in SCOPe 2.03
  
• d2zkhh1 appears in SCOPe 2.05
  
• d2zkhh1 appears in SCOPe 2.07
  
• d2zkhh1 appears in the current release, SCOPe 2.08