SCOPe 2.08: Domain d2v4la1: 2v4l A:144-322

Lineage for d2v4la1 (2v4l A:144-322)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (15 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (11 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (77 PDB entries)

8. Domain d2v4la1: 2v4l A:144-322 [206203]
   Other proteins in same PDB: d2v4la2, d2v4la3, d2v4la4
   automated match to d1e8ya3
   complexed with abj
   has additional insertions and/or extensions that are not grouped together

Details for d2v4la1

PDB Entry: 2v4l, 2.5 Å

PDB Description: complex of human phosphoinositide 3-kinase catalytic subunit gamma (p110 gamma) with PIK-284

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d2v4la1:

Sequence, based on SEQRES records:

>d2v4la1 d.15.1.5 (A:144-322) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee

Sequence, based on observed residues (ATOM records):

>d2v4la1 d.15.1.5 (A:144-322) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakqdfvlrvcg
rdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee

Timeline for d2v4la1:

• d2v4la1 first appeared in SCOPe 2.03
  
• d2v4la1 appears in SCOPe 2.07