SCOPe 2.03: Domain d2p4ib_: 2p4i B:

Lineage for d2p4ib_ (2p4i B:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (11 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (418 PDB entries)

8. Domain d2p4ib_: 2p4i B: [205438]
   automated match to d2oo8x_
   complexed with mr9

Details for d2p4ib_

PDB Entry: 2p4i, 2.5 Å

PDB Description: Evolution of a highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor

PDB Compounds: (B:) Angiopoietin-1 receptor

SCOPe Domain Sequences for d2p4ib_:

Sequence, based on SEQRES records:

>d2p4ib_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gqvlkarikkdglrmdaaikrmkeyaskddhrdfagelevlcklghhpniinllgacehr
gylylaieyaphgnlldflrksrvletdpafaianstastlssqqllhfaadvargmdyl
sqkqfihrdlaarnilvgenyvakiadfglsrgqevyvkktmgrlpvrwmaieslnysvy
ttnsdvwsygvllweivslggtpycgmtcaelyeklpqgyrlekplncddevydlmrqcw
rekpyerpsfaqilvslnrmleerktyvnttlyekftyagid

Sequence, based on observed residues (ATOM records):

>d2p4ib_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gqvlkarirmdaaikrmkekddhrdfagelevlcklghhpniinllgacehylaieyaph
gnlldflrksrvletdpafaianstastlssqqllhfaadvargmdylsqkqfihrdlaa
rnilvgenyvakiadfglgrlpvrwmaieslnysvyttnsdvwsygvllweivslggtpy
cgmtcaelyeklpqgyrlekplncddevydlmrqcwrekpyerpsfaqilvslnrmleer
ktyvnttlyekftyagid

Timeline for d2p4ib_:

• d2p4ib_ is new in SCOPe 2.03-stable
  
• d2p4ib_ appears in SCOPe 2.04
  
• d2p4ib_ appears in the current release, SCOPe 2.08