SCOPe 2.05: Domain d1cu4h1: 1cu4 H:3-110

Lineage for d1cu4h1 (1cu4 H:3-110)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.1 [TaxId:10090] [88551] (31 PDB entries)
   SQ NA # natural chimera; best hits are: Uniprot P01751 (Ig heavy chain V region B1-8/186-2) and Uniprot P01864 (Ig gamma-2A chain C region secreted form)

8. Domain d1cu4h1: 1cu4 H:3-110 [20433]
   Other proteins in same PDB: d1cu4h2, d1cu4l1, d1cu4l2
   part of anti-prion Fab 3F4

Details for d1cu4h1

PDB Entry: 1cu4, 2.9 Å

PDB Description: crystal structure of the anti-prion fab 3f4 in complex with its peptide epitope

PDB Compounds: (H:) Fab heavy chain

SCOPe Domain Sequences for d1cu4h1:

Sequence; same for both SEQRES and ATOM records:

>d1cu4h1 b.1.1.1 (H:3-110) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.1 [TaxId: 10090]}
klqqsgaelvrsgasvklsctasgfnikdyyiqwvkqrpeqglewigwidpengnseyap
rfqgkatmtadtlsntaylqlssltsedtavyycnadlhdywgqgttltvss

Timeline for d1cu4h1:

• d1cu4h1 first appeared (with stable ids) in SCOP 1.55
  
• d1cu4h1 appears in SCOPe 2.04
  
• d1cu4h1 appears in SCOPe 2.06
  
• d1cu4h1 appears in the current release, SCOPe 2.08