SCOPe 2.07: Domain d1ejoh1: 1ejo H:2501-2619

Lineage for d1ejoh1 (1ejo H:2501-2619)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 2.2 [TaxId:10090] [88550] (61 PDB entries)
   Uniprot P01811 # HV41_MOUSE (P01811) Ig heavy chain V region UPC10

8. Domain d1ejoh1: 1ejo H:2501-2619 [20429]
   Other proteins in same PDB: d1ejoh2, d1ejol1, d1ejol2
   part of anti-FMDV Fab 4C4

Details for d1ejoh1

PDB Entry: 1ejo, 2.3 Å

PDB Description: fab fragment of neutralising monoclonal antibody 4c4 complexed with g- h loop from fmdv.

PDB Compounds: (H:) igg2a monoclonal antibody (heavy chain)

SCOPe Domain Sequences for d1ejoh1:

Sequence; same for both SEQRES and ATOM records:

>d1ejoh1 b.1.1.1 (H:2501-2619) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 2.2 [TaxId: 10090]}
qmlvesggdlvkpggslklscaasgftfssytmswvrqtpekrlewvatissggaytyyp
dsvkgrftisddnaestlylqmsslrsedtamyycvrrafdsdvgfaswghrtlvtvsa

Timeline for d1ejoh1:

• d1ejoh1 first appeared (with stable ids) in SCOP 1.55
  
• d1ejoh1 appears in SCOPe 2.06
  
• d1ejoh1 appears in the current release, SCOPe 2.08