SCOP 1.65: Domain d1sm3h1: 1sm3 H:1-113

Lineage for d1sm3h1 (1sm3 H:1-113)

1. Root: SCOP 1.65

2. Class b: All beta proteins [48724] (126 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (20 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (21 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (19 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogeneous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1 [TaxId:10090] [88548] (22 PDB entries)

8. Domain d1sm3h1: 1sm3 H:1-113 [20369]
   Other proteins in same PDB: d1sm3h2, d1sm3l1, d1sm3l2
   part of tumor-specific Fab SM3 against epithelial mucin Muc1
   complexed with cd, cl

Details for d1sm3h1

PDB Entry: 1sm3, 1.95 Å

PDB Description: crystal structure of the tumor specific antibody sm3 complex with its peptide epitope

SCOP Domain Sequences for d1sm3h1:

Sequence; same for both SEQRES and ATOM records:

>d1sm3h1 b.1.1.1 (H:1-113) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 1}
qvqlqesggglvqpggsmklscvasgftfsnywmnwvrqspekglewvaeirlksnnyat
hyaesvkgrftisrddskssvylqmnnlraedtgiyyctgvgqfaywgqgttvtvss

Timeline for d1sm3h1:

• d1sm3h1 first appeared (with stable ids) in SCOP 1.55
  
• d1sm3h1 appears in SCOP 1.63
  
• d1sm3h1 appears in SCOP 1.67
  
• d1sm3h1 appears in the current release, SCOPe 2.08