SCOPe 2.06: Domain d2aw5b2: 2aw5 B:270-555

Lineage for d2aw5b2 (2aw5 B:270-555)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.0: automated matches [191313] (1 protein)
   not a true family

6. Protein automated matches [190069] (239 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186944] (46 PDB entries)

8. Domain d2aw5b2: 2aw5 B:270-555 [203501]
   Other proteins in same PDB: d2aw5a1, d2aw5b1, d2aw5c1
   automated match to d1gq2a1

Details for d2aw5b2

PDB Entry: 2aw5, 2.5 Å

PDB Description: Crystal structure of a human malic enzyme

PDB Compounds: (B:) NADP-dependent malic enzyme

SCOPe Domain Sequences for d2aw5b2:

Sequence, based on SEQRES records:

>d2aw5b2 c.2.1.0 (B:270-555) automated matches {Human (Homo sapiens) [TaxId: 9606]}
iqgtasvavagllaalritknklsdqtilfqgageaalgiahlivmalekeglpkekaik
kiwlvdskglivkgrasltqekekfaheheemknleaivqeikptaligvaaiggafseq
ilkdmaafnerpiifalsnptskaecsaeqcykitkgraifasgspfdpvtlpngqtlyp
gqgnnsyvfpgvalgvvacglrqitdniflttaeviaqqvsdkhleegrlypplntirdv
slkiaekivkdayqektatvypepqnkeafvrsqmystdydqilpd

Sequence, based on observed residues (ATOM records):

>d2aw5b2 c.2.1.0 (B:270-555) automated matches {Human (Homo sapiens) [TaxId: 9606]}
iqgtasvavagllaalritknklsdqtilfqgageaalgiahlivmalekeglpkekaik
kiwlvdskglivkgqekekfaheheemknleaivqeikptaligvaaiggafseqilkdm
aafnerpiifalsnptskaecsaeqcykitkgraifasgspfdpvtlpngqtlypgqgnn
syvfpgvalgvvacglrqitdniflttaeviaqqvsdkhleegrlypplntirdvslkia
ekivkdayqektatvypepqnkeafvrsqmystdydqilpd

Timeline for d2aw5b2:

• d2aw5b2 first appeared in SCOPe 2.03
  
• d2aw5b2 appears in SCOPe 2.05
  
• d2aw5b2 appears in SCOPe 2.07
  
• d2aw5b2 appears in the current release, SCOPe 2.08