SCOP 1.73: Domain d1cz8y1: 1cz8 Y:1-123

Lineage for d1cz8y1 (1cz8 Y:1-123)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (27 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (29 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (20 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88554] (32 PDB entries)

8. Domain d1cz8y1: 1cz8 Y:1-123 [20329]
   Other proteins in same PDB: d1cz8h2, d1cz8l1, d1cz8l2, d1cz8v_, d1cz8w_, d1cz8x1, d1cz8x2, d1cz8y2
   part of humanized Fab-12 neutralizing VEGF; affinity matured
   complexed with so4; mutant

Details for d1cz8y1

PDB Entry: 1cz8, 2.4 Å

PDB Description: vascular endothelial growth factor in complex with an affinity matured antibody

PDB Compounds: (Y:) heavy chain of neutralizing antibody

SCOP Domain Sequences for d1cz8y1:

Sequence; same for both SEQRES and ATOM records:

>d1cz8y1 b.1.1.1 (Y:1-123) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 4 [TaxId: 10090]}
evqlvesggglvqpggslrlscaasgydfthygmnwvrqapgkglewvgwintytgepty
aadfkrrftfsldtskstaylqmnslraedtavyycakypyyygtshwyfdvwgqgtlvt
vss

Timeline for d1cz8y1:

• d1cz8y1 first appeared (with stable ids) in SCOP 1.55
  
• d1cz8y1 appears in SCOP 1.71
  
• d1cz8y1 appears in SCOP 1.75
  
• d1cz8y1 appears in the current release, SCOPe 2.08