SCOPe 2.05: Domain d1bj1h1: 1bj1 H:1-123

Lineage for d1bj1h1 (1bj1 H:1-123)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88554] (34 PDB entries)
   Uniprot P06327 20-117 # HV52_MOUSE (P06327) Ig heavy chain V region VH558 A1/A4 precursor; 57% sequence identity ! Uniprot P01631 # KV2G_MOUSE (P01631) Ig kappa chain V-II region 26-10

8. Domain d1bj1h1: 1bj1 H:1-123 [20323]
   Other proteins in same PDB: d1bj1h2, d1bj1j1, d1bj1j2, d1bj1k2, d1bj1l1, d1bj1l2, d1bj1v_, d1bj1w_
   part of humanized Fab-12 neutralizing VEGF
   complexed with so4

Details for d1bj1h1

PDB Entry: 1bj1, 2.4 Å

PDB Description: vascular endothelial growth factor in complex with a neutralizing antibody

PDB Compounds: (H:) fab fragment

SCOPe Domain Sequences for d1bj1h1:

Sequence; same for both SEQRES and ATOM records:

>d1bj1h1 b.1.1.1 (H:1-123) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 4 [TaxId: 10090]}
evqlvesggglvqpggslrlscaasgytftnygmnwvrqapgkglewvgwintytgepty
aadfkrrftfsldtskstaylqmnslraedtavyycakyphyygsshwyfdvwgqgtlvt
vss

Timeline for d1bj1h1:

• d1bj1h1 first appeared (with stable ids) in SCOP 1.55
  
• d1bj1h1 appears in SCOPe 2.04
  
• d1bj1h1 appears in SCOPe 2.06
  
• d1bj1h1 appears in the current release, SCOPe 2.08