SCOPe 2.01: Domain d1bvla_: 1bvl A:

Lineage for d1bvla_ (1bvl A:)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Engineered (including hybrid species) [88562] (67 PDB entries)
   SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # humanized antibody ! SQ NA # Humanized antibody ! SQ NA # engineered antibody

8. Domain d1bvla_: 1bvl A: [20282]
   Other proteins in same PDB: d1bvlb_, d1bvld_
   part of humanized anti-lysozyme Fv HuLys11

Details for d1bvla_

PDB Entry: 1bvl, 2.87 Å

PDB Description: humanized anti-lysozyme fv

PDB Compounds: (A:) hulys11

SCOPe Domain Sequences for d1bvla_:

Sequence; same for both SEQRES and ATOM records:

>d1bvla_ b.1.1.1 (A:) Immunoglobulin heavy chain variable domain, VH {Engineered (including hybrid species)}
qvqlqesgpglvrpsqtlsltctvsgfsltgygvnwvrqppgrglewigmiwgdgntdyn
salksrvtmlkdtsknqfslrlssvtaadtavyycarerdyrldywgqgslvtvss

Timeline for d1bvla_:

• d1bvla_ first appeared (with stable ids) in SCOP 1.55
  
• d1bvla_ appears in SCOP 1.75
  
• d1bvla_ appears in SCOPe 2.02
  
• d1bvla_ appears in the current release, SCOPe 2.08, called d1bvla1