SCOPe 2.06: Domain d4iwha1: 4iwh A:1-355

Lineage for d4iwha1 (4iwh A:1-355)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein automated matches [190072] (19 species)
   not a true protein

7. Species Burkholderia thailandensis [TaxId:271848] [193254] (1 PDB entry)

8. Domain d4iwha1: 4iwh A:1-355 [202678]
   Other proteins in same PDB: d4iwha2
   automated match to d4iwhb_
   complexed with mg

Details for d4iwha1

PDB Entry: 4iwh, 1.75 Å

PDB Description: Crystal structure of a 3-isopropylmalate dehydrogenase from Burkholderia pseudomallei

PDB Compounds: (A:) 3-isopropylmalate dehydrogenase

SCOPe Domain Sequences for d4iwha1:

Sequence; same for both SEQRES and ATOM records:

>d4iwha1 c.77.1.1 (A:1-355) automated matches {Burkholderia thailandensis [TaxId: 271848]}
mkiavlpgdgigpeivneavkvlnaldekfelehapvggagyeasghplpdatlalakea
dailfgavgdwkydsleralrpeqailglrkhlelfanfrpaicypqlvdasplkpelva
gldilivrelngdiyfgqprgvraapdgpfageregfdtmrysepevrriahvafqaaqk
rakkllsvdksnvletsqfwrdvmidvskeyadvelshmyvdnaamqlakapkqfdvivt
gnmfgdilsdeasmltgsigmlpsasldknnkglyepshgsapdiagkgianplatilsa
amllryslnraeqadrieravktvleqgyrtgdiatpgcrqvgtaamgdavvaal

Timeline for d4iwha1:

• d4iwha1 first appeared in SCOPe 2.03, called d4iwha_
  
• d4iwha1 was called d4iwha_ in SCOPe 2.05
  
• d4iwha1 appears in SCOPe 2.07
  
• d4iwha1 appears in the current release, SCOPe 2.08