SCOPe 2.03: Domain d1a4jh1: 1a4j H:1-119

Lineage for d1a4jh1 (1a4j H:1-119)

Root: SCOPe 2.03
Class b: All beta proteins [48724] (174 folds)
Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
sandwich; 7 strands in 2 sheets; greek-key
some members of the fold have additional strands
Superfamily b.1.1: Immunoglobulin [48726] (5 families)
Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88554] (34 PDB entries)
Uniprot P06327 20-117 # HV52_MOUSE (P06327) Ig heavy chain V region VH558 A1/A4 precursor; 57% sequence identity ! Uniprot P01631 # KV2G_MOUSE (P01631) Ig kappa chain V-II region 26-10

Domain d1a4jh1: 1a4j H:1-119 [20231]
Other proteins in same PDB: d1a4ja1, d1a4ja2, d1a4jb2, d1a4jh2, d1a4jl1, d1a4jl2
part of humanized Diels-Alder catalytic Fab

Details for d1a4jh1

PDB Entry: 1a4j (more details), 2.1 Å

PDB Description: diels alder catalytic antibody germline precursor

PDB Compounds: (H:) immunoglobulin, diels alder catalytic antibody (heavy chain)

SCOPe Domain Sequences for d1a4jh1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1a4jh1 b.1.1.1 (H:1-119) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 4 [TaxId: 10090]}
qvqllesgpelkkpgetvkisckasgytftnygmnwvkqapgkglkwmgwintytgepty
addfkgrfafsletsastaylqinnlknedtatyfcvqaerlrrtfdywgagttvtvss

SCOPe Domain Coordinates for d1a4jh1:

Click to download the PDB-style file with coordinates for d1a4jh1.
(The format of our PDB-style files is described here.)

Timeline for d1a4jh1: