SCOPe 2.07: Domain d1pskh1: 1psk H:1-114

Lineage for d1pskh1 (1psk H:1-114)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (184 PDB entries)
   Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E ! SQ NA # humanized antibody ! Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor ! Uniprot P01750 20-116 # ! HV06_MOUSE Ig heavy chain V region 102 precursor

8. Domain d1pskh1: 1psk H:1-114 [20139]
   Other proteins in same PDB: d1pskh2, d1pskl1, d1pskl2
   part of antibody against the melanoma associated gd2 ganglioside

Details for d1pskh1

PDB Entry: 1psk, 2.8 Å

PDB Description: the crystal structure of an fab fragment that binds to the melanoma-associated gd2 ganglioside

PDB Compounds: (H:) antibody

SCOPe Domain Sequences for d1pskh1:

Sequence; same for both SEQRES and ATOM records:

>d1pskh1 b.1.1.1 (H:1-114) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
evqlqqsgpelvkpgasvkiscktsgytftkytmhwvkqshgkslewigdinpnnggtny
nqkfkgtatltvhkssttaymelrsltsedsavyyctsksfdywgqgttltvss

Timeline for d1pskh1:

• d1pskh1 first appeared (with stable ids) in SCOP 1.55
  
• d1pskh1 appears in SCOPe 2.06
  
• d1pskh1 appears in the current release, SCOPe 2.08