SCOPe 2.03: Domain d3v5ld_: 3v5l D:

Lineage for d3v5ld_ (3v5l D:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
   PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111195] (26 PDB entries)
   Uniprot Q08881 357-619

8. Domain d3v5ld_: 3v5l D: [201200]
   automated match to d3v8wb_
   complexed with 0g1, so4

Details for d3v5ld_

PDB Entry: 3v5l, 1.86 Å

PDB Description: crystal structure of interleukin-2 inducible t-cell kinase itk catalytic domain with thienopyrazolylindole inhibitor 542

PDB Compounds: (D:) Tyrosine-protein kinase ITK/TSK

SCOPe Domain Sequences for d3v5ld_:

Sequence, based on SEQRES records:

>d3v5ld_ d.144.1.7 (D:) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
gsvidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmkls
hpklvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayle
eacvihrdlaarnclvgenqvikvsdfgmtrfvlddqytsstgtkfpvkwaspevfsfsr
yssksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhc
wkerpedrpafsrllrqlaeiaesg

Sequence, based on observed residues (ATOM records):

>d3v5ld_ d.144.1.7 (D:) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
gsvidpseltfvqeigsgqglvhlgywlnkdkvaiktiramseedfieeaevmmklshpk
lvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeac
vihrdlaarnclvgenqvikvsdfgmfpvkwaspevfsfsryssksdvwsfgvlmwevfs
egkipyenrsnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqla
eiaesg

Timeline for d3v5ld_:

• d3v5ld_ is new in SCOPe 2.03-stable
  
• d3v5ld_ appears in SCOPe 2.04
  
• d3v5ld_ appears in the current release, SCOPe 2.08, called d3v5ld1