SCOPe 2.05: Domain d1mlbb1: 1mlb B:1-118

Lineage for d1mlbb1 (1mlb B:1-118)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (178 PDB entries)
   Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E ! SQ NA # humanized antibody ! Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor ! Uniprot P01750 20-116 # ! HV06_MOUSE Ig heavy chain V region 102 precursor

8. Domain d1mlbb1: 1mlb B:1-118 [20051]
   Other proteins in same PDB: d1mlba1, d1mlba2, d1mlbb2
   part of Fab D44.1

Details for d1mlbb1

PDB Entry: 1mlb, 2.1 Å

PDB Description: monoclonal antibody fab d44.1 raised against chicken egg-white lysozyme

PDB Compounds: (B:) igg1-kappa d44.1 fab (heavy chain)

SCOPe Domain Sequences for d1mlbb1:

Sequence; same for both SEQRES and ATOM records:

>d1mlbb1 b.1.1.1 (B:1-118) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
qvqlqesgaevmkpgasvkisckatgytfstywiewvkqrpghglewigeilpgsgstyy
nekfkgkatftadtssntaymqlssltsedsavyycargdgnygywgqgttltvssas

Timeline for d1mlbb1:

• d1mlbb1 first appeared (with stable ids) in SCOP 1.55
  
• d1mlbb1 appears in SCOPe 2.04
  
• d1mlbb1 appears in SCOPe 2.06
  
• d1mlbb1 appears in the current release, SCOPe 2.08