SCOP 1.75: Domain d1mrel1: 1mre L:1-108

Lineage for d1mrel1 (1mre L:1-108)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (32 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1.1 [TaxId:10090] [88524] (127 PDB entries)
   Uniprot P01631 #KV2G_MOUSE Ig kappa chain V-II region 26-10; 79% sequence identity
   Uniprot P06310 # KV2F_HUMAN IG KAPPA CHAIN V-II REGION RPMI 6410 PRECURSOR
   Uniprot P03976 # KV2E_MOUSE (P03976) Ig kappa chain V-II region 17S29.1
   Uniprot P01642 21-115 #
   KV2G_MOUSE IG KAPPA CHAIN V-II REGION 26-10
   Uniprot P01631 #KV2G_MOUSE Ig kappa chain V-II region 26-10; 79% sequence identity ! Uniprot P06310 # KV2F_HUMAN IG KAPPA CHAIN V-II REGION RPMI 6410 PRECURSOR ! Uniprot P03976 # KV2E_MOUSE (P03976) Ig kappa chain V-II region 17S29.1 ! Uniprot P01642 21-115 # ! KV2G_MOUSE IG KAPPA CHAIN V-II REGION 26-10

8. Domain d1mrel1: 1mre L:1-108 [20018]
   Other proteins in same PDB: d1mreh1, d1mreh2, d1mrel2
   part of Fab Jel 103
   complexed with gdp, imd, zn

Details for d1mrel1

PDB Entry: 1mre, 2.3 Å

PDB Description: preparation, characterization and crystallization of an antibody fab fragment that recognizes rna. crystal structures of native fab and three fab-mononucleotide complexes

PDB Compounds: (L:) igg2b-kappa jel103 fab (light chain)

SCOP Domain Sequences for d1mrel1:

Sequence; same for both SEQRES and ATOM records:

>d1mrel1 b.1.1.1 (L:1-108) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 1.1 [TaxId: 10090]}
dvvmtqtplslpvslgdqasiscrssqslvhsngntylhwylqkpgqspklliykvsnrf
sgvpdrfsgsgsgtdftlkisrveaedlgvyfcsqsthvprtfgggtkleikr

Timeline for d1mrel1:

• d1mrel1 first appeared (with stable ids) in SCOP 1.55
  
• d1mrel1 appears in SCOP 1.73
  
• d1mrel1 appears in SCOPe 2.01
  
• d1mrel1 appears in the current release, SCOPe 2.08