SCOPe 2.04: Domain d1knob1: 1kno B:1-119

Lineage for d1knob1 (1kno B:1-119)

Root: SCOPe 2.04
Class b: All beta proteins [48724] (176 folds)
Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
sandwich; 7 strands in 2 sheets; greek-key
some members of the fold have additional strands
Superfamily b.1.1: Immunoglobulin [48726] (5 families)
Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

Species Mouse (Mus musculus), cluster 2.2 [TaxId:10090] [88550] (58 PDB entries)
Uniprot P01811 # HV41_MOUSE (P01811) Ig heavy chain V region UPC10
Domain d1knob1: 1kno B:1-119 [20009]
Other proteins in same PDB: d1knoa1, d1knoa2, d1knob2, d1knoc1, d1knoc2, d1knod2, d1knoe1, d1knoe2, d1knof2
part of Fab CNJ206
complexed with pnp, zn

Details for d1knob1

PDB Entry: 1kno (more details), 3.2 Å

PDB Description: crystal structure of the complex of a catalytic antibody fab with a transition state analog: structural similarities in esterase-like abzymes

PDB Compounds: (B:) igg2a fab fragment cnj206

SCOPe Domain Sequences for d1knob1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1knob1 b.1.1.1 (B:1-119) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 2.2 [TaxId: 10090]}
dvklvesggglvqpggsrklscaasgftfssfgmhwvrqapekglewvayissgsstiyy
adtvkgrftisrdnpkntlflqmtslrsedtamyycargdyygsrgaywgqgtlvtvsa

SCOPe Domain Coordinates for d1knob1:

Click to download the PDB-style file with coordinates for d1knob1.
(The format of our PDB-style files is described here.)

Timeline for d1knob1: