SCOP 1.75: Domain d1ncbl1: 1ncb L:1-108

Lineage for d1ncbl1 (1ncb L:1-108)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (32 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88531] (182 PDB entries)
   Uniprot P01645 1-106 # 95% sequense identity; KV5L_MOUSE Ig kappa chain V-V region HP 93G7
   SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region)
   SQ NA # humanized antibody
   SQ NA # part of Fab 28 against HIV-1 RT
   Uniprot P01642 21-115 #
   KV5I_MOUSE Ig kappa chain V-V region L7 precursor
   Uniprot P01645 1-106 # 95% sequense identity; KV5L_MOUSE Ig kappa chain V-V region HP 93G7 ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! SQ NA # humanized antibody ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01642 21-115 # ! KV5I_MOUSE Ig kappa chain V-V region L7 precursor

8. Domain d1ncbl1: 1ncb L:1-108 [19980]
   Other proteins in same PDB: d1ncbh1, d1ncbh2, d1ncbl2, d1ncbn_
   part of Fab NC41
   complexed with ca, man, nag; mutant

Details for d1ncbl1

PDB Entry: 1ncb, 2.5 Å

PDB Description: crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface

PDB Compounds: (L:) igg2a-kappa nc41 fab (light chain)

SCOP Domain Sequences for d1ncbl1:

Sequence; same for both SEQRES and ATOM records:

>d1ncbl1 b.1.1.1 (L:1-108) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 4 [TaxId: 10090]}
divmtqspkfmstsvgdrvtitckasqdvstavvwyqqkpgqspklliywastrhigvpd
rfagsgsgtdytltissvqaedlalyycqqhysppwtfgggtkleikr

Timeline for d1ncbl1:

• d1ncbl1 first appeared (with stable ids) in SCOP 1.55
  
• d1ncbl1 appears in SCOP 1.73
  
• d1ncbl1 appears in SCOPe 2.01
  
• d1ncbl1 appears in the current release, SCOPe 2.08