SCOPe 2.03: Domain d3efwb_: 3efw B:

Lineage for d3efwb_ (3efw B:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Aurora-related kinase 1 (aurora-2) [90038] (1 species)
   OPK group; AIRK subfamily; serine/threonine kinase
7. Species Human (Homo sapiens) [TaxId:9606] [90039] (17 PDB entries)

8. Domain d3efwb_: 3efw B: [199327]
   automated match to d3o50b_
   complexed with ak8, so4

Details for d3efwb_

PDB Entry: 3efw, 2.29 Å

PDB Description: Structure of AuroraA with pyridyl-pyrimidine urea inhibitor

PDB Compounds: (B:) serine/threonine-protein kinase 6

SCOPe Domain Sequences for d3efwb_:

Sequence, based on SEQRES records:

>d3efwb_ d.144.1.7 (B:) Aurora-related kinase 1 (aurora-2) {Human (Homo sapiens) [TaxId: 9606]}
rqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiq
shlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanals
ychskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylppemiegrm
hdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllk
hnpsqrpmlrevlehpwitanssk

Sequence, based on observed residues (ATOM records):

>d3efwb_ d.144.1.7 (B:) Aurora-related kinase 1 (aurora-2) {Human (Homo sapiens) [TaxId: 9606]}
rqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiq
shlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanals
ychskrvihrdikpenlllgsagelkiadfldylppemieekvdlwslgvlcyeflvgkp
pfeantyqetykrisrveftfpdfvtegardlisrllkhnpsqrpmlrevlehpwitans
sk

Timeline for d3efwb_:

• d3efwb_ is new in SCOPe 2.03-stable
  
• d3efwb_ appears in SCOPe 2.04
  
• d3efwb_ appears in the current release, SCOPe 2.08