SCOPe 2.08: Domain d1mfeh1: 1mfe H:251-367

Lineage for d1mfeh1 (1mfe H:251-367)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (181 PDB entries)
   Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E ! SQ NA # humanized antibody ! Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor ! Uniprot P01750 20-116 # ! HV06_MOUSE Ig heavy chain V region 102 precursor

8. Domain d1mfeh1: 1mfe H:251-367 [19893]
   Other proteins in same PDB: d1mfeh2, d1mfel1, d1mfel2
   part of Fab SE155-4

Details for d1mfeh1

PDB Entry: 1mfe, 2 Å

PDB Description: recognition of a cell-surface oligo-saccharide of pathogenic salmonella by an antibody fab fragment

PDB Compounds: (H:) igg1-lambda se155-4 fab (heavy chain)

SCOPe Domain Sequences for d1mfeh1:

Sequence, based on SEQRES records:

>d1mfeh1 b.1.1.1 (H:251-367) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
evqvqqsgtvlarpgasvkmsckasgytftnywmhwikqrpgqglewigaiypgnsatfy
nhkfraktkltavtstitaymelssltnedsavyyctrgghgyygdywgqgasltvs

Sequence, based on observed residues (ATOM records):

>d1mfeh1 b.1.1.1 (H:251-367) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
evqvqqsgtvlarpgasvkmsckasgytftnywmhwikqrpgglewigaiypgnsatfyn
hkfraktkltavtstitaymelssltnedsavyyctrgghgyygdywgqgasltvs

Timeline for d1mfeh1:

• d1mfeh1 first appeared (with stable ids) in SCOP 1.55
  
• d1mfeh1 appears in SCOPe 2.07