SCOP 1.75: Domain d1bbjh1: 1bbj H:1-115

Lineage for d1bbjh1 (1bbj H:1-115)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (32 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (152 PDB entries)
   Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E
   SQ NA # humanized antibody
   Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor
   Uniprot P01750 20-116 #
   HV06_MOUSE Ig heavy chain V region 102 precursor
   Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E ! SQ NA # humanized antibody ! Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor ! Uniprot P01750 20-116 # ! HV06_MOUSE Ig heavy chain V region 102 precursor

8. Domain d1bbjh1: 1bbj H:1-115 [19785]
   Other proteins in same PDB: d1bbja1, d1bbja2, d1bbjb2, d1bbjh2, d1bbjl1, d1bbjl2
   part of humanized Fab B72.3

Details for d1bbjh1

PDB Entry: 1bbj, 3.1 Å

PDB Description: crystal structure of a chimeric fab' fragment of an antibody binding tumour cells

PDB Compounds: (H:) igg4-kappa b72.3 fab (heavy chain)

SCOP Domain Sequences for d1bbjh1:

Sequence; same for both SEQRES and ATOM records:

>d1bbjh1 b.1.1.1 (H:1-115) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
evqlqqsdaelvkpgasvkisckasgytftdhaihwakqkpeqglewigyispgnddiky
nekfkgkatltadkssstaymqlnsltsedsavyfckrsyyghwgqgttltvssa

Timeline for d1bbjh1:

• d1bbjh1 first appeared (with stable ids) in SCOP 1.55
  
• d1bbjh1 appears in SCOP 1.73
  
• d1bbjh1 appears in SCOPe 2.01
  
• d1bbjh1 appears in the current release, SCOPe 2.08