Lineage for d3rtpa_ (3rtp A:)

  1. Root: SCOPe 2.08
  2. 2923792Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. 2979545Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2979546Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2979693Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2979887Protein c-jun N-terminal kinase (jnk3s) [56137] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  7. 2979888Species Human (Homo sapiens) [TaxId:9606] [56138] (50 PDB entries)
  8. 2979924Domain d3rtpa_: 3rtp A: [197064]
    automated match to d2xrwa_
    complexed with 34i

Details for d3rtpa_

PDB Entry: 3rtp (more details), 2.4 Å

PDB Description: Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration
PDB Compounds: (A:) Mitogen-activated protein kinase 10

SCOPe Domain Sequences for d3rtpa_:

Sequence, based on SEQRES records: (download)

>d3rtpa_ d.144.1.7 (A:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
nqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqtha
krayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldher
msyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfmmtpyvv
tryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpe
fmkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpa
krisvddalqhpyinvwydpaeveapppqiydkqlderehtieewkeliykevmn

Sequence, based on observed residues (ATOM records): (download)

>d3rtpa_ d.144.1.7 (A:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
nqfysvevgdstftvlkryqnlkpigsgivcaaydavldrnvaikklsrpfqnqthakra
yrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhermsy
llyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfgltryyrapevilgmgyken
vdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkklqptvrnyvenrpk
yagltfpklfpdslfpadsehnklkasqardllskmlvidpakrisvddalqhpyinvwy
dpaeveappplderehtieewkeliykevmn

SCOPe Domain Coordinates for d3rtpa_:

Click to download the PDB-style file with coordinates for d3rtpa_.
(The format of our PDB-style files is described here.)

Timeline for d3rtpa_: