SCOPe 2.04: Domain d4g3yc_: 4g3y C:

Lineage for d4g3yc_ (4g3y C:)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.22: TNF-like [49841] (1 superfamily)
   sandwich, 10 strands in 2 sheets; jelly-roll

4. Superfamily b.22.1: TNF-like [49842] (2 families)

5. Family b.22.1.1: TNF-like [49843] (15 proteins)

6. Protein Tumor necrosis factor (TNF) [49848] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49849] (13 PDB entries)

8. Domain d4g3yc_: 4g3y C: [196713]
   Other proteins in same PDB: d4g3yl1, d4g3yl2
   automated match to d1a8ma_

Details for d4g3yc_

PDB Entry: 4g3y, 2.6 Å

PDB Description: Crystal structure of TNF-alpha in complex with Infliximab Fab fragment

PDB Compounds: (C:) Tumor necrosis factor

SCOPe Domain Sequences for d4g3yc_:

Sequence; same for both SEQRES and ATOM records:

>d4g3yc_ b.22.1.1 (C:) Tumor necrosis factor (TNF) {Human (Homo sapiens) [TaxId: 9606]}
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
drlsaeinrpdyldfaesgqvyfgiial

Timeline for d4g3yc_:

• d4g3yc_ first appeared in SCOPe 2.02
  
• d4g3yc_ appears in SCOPe 2.03
  
• d4g3yc_ appears in SCOPe 2.05
  
• d4g3yc_ appears in the current release, SCOPe 2.08