SCOPe 2.08: Domain d3gena_: 3gen A:

Lineage for d3gena_ (3gen A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d3gena_: 3gen A: [196488]
   automated match to d3pj2a_
   complexed with b43

Details for d3gena_

PDB Entry: 3gen, 1.6 Å

PDB Description: The 1.6 A crystal structure of human bruton's tyrosine kinase bound to a pyrrolopyrimidine-containing compound

PDB Compounds: (A:) Tyrosine-protein kinase BTK

SCOPe Domain Sequences for d3gena_:

Sequence, based on SEQRES records:

>d3gena_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ygsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmn
lsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceamey
leskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmy
skfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimy
scwhekaderptfkillsnildvmdee

Sequence, based on observed residues (ATOM records):

>d3gena_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ygsweidpkdltflkelgfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlsh
eklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyles
kqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskf
ssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimyscw
hekaderptfkillsnildvmdee

Timeline for d3gena_:

• d3gena_ first appeared in SCOPe 2.02
  
• d3gena_ appears in SCOPe 2.07