SCOPe 2.02: Domain d3ds9a_: 3ds9 A:

Lineage for d3ds9a_ (3ds9 A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

5. Family d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (2 proteins)

6. Protein Botulinum neurotoxin [55513] (4 species)

7. Species Clostridium botulinum, serotype A [TaxId:1491] [55514] (13 PDB entries)
   Uniprot P10845 1-419

8. Domain d3ds9a_: 3ds9 A: [196053]
   automated match to d3nf3a_
   complexed with ni, zn

Details for d3ds9a_

PDB Entry: 3ds9, 1.76 Å

PDB Description: A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate

PDB Compounds: (A:) Botulinum neurotoxin type A

SCOPe Domain Sequences for d3ds9a_:

Sequence, based on SEQRES records:

>d3ds9a_ d.92.1.7 (A:) Botulinum neurotoxin {Clostridium botulinum, serotype A [TaxId: 1491]}
fvnkqfnykdpvngvdiayikipnagqmqpvkafkihnkiwviperdtftnpeegdlnpp
peakqvpvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwggst
idtelkvidtncinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltrngygs
tqyirfspdftfgfeeslevdtnpllgagkfatdpavtlahelihaghrlygiainpnrv
fkvntnayyemsglevsfeelrtfgghdakfidslqenefrlyyynkfkdiastlnkaks
ivgttaslqymknvfkekyllsedtsgkfsvdklkfdklykmlteiytednfvkffkvln
rktylnfdkavfkinivpkvnytiydgfnlrntnlaanfngqnteinnmnftklk

Sequence, based on observed residues (ATOM records):

>d3ds9a_ d.92.1.7 (A:) Botulinum neurotoxin {Clostridium botulinum, serotype A [TaxId: 1491]}
fvnkqfnykdpvngvdiayikipnamqpvkafkihnkiwviperdtftnpeegdlnpppe
akqvpvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwggstid
telkvidtncinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltrngygstq
yirfspdftfgfeeagkfatdpavtlahelihaghrlygiainpnrvfkvntnasglevs
feelrtfgghdakfidslqenefrlyyynkfkdiastlnkaksivgttaslqymknvfke
kyllsedtsgkfsvdklkfdklykmlteiytednfvkffkvlnrktylnfdkavfkiniv
pkvnytiydgfnlrntnlaanfngqnteinnmnftklk

Timeline for d3ds9a_:

• d3ds9a_ is new in SCOPe 2.02-stable
  
• d3ds9a_ appears in SCOPe 2.03
  
• d3ds9a_ appears in the current release, SCOPe 2.08