SCOPe 2.03: Domain d4af3a_: 4af3 A:

Lineage for d4af3a_ (4af3 A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (11 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (418 PDB entries)

8. Domain d4af3a_: 4af3 A: [195639]
   automated match to d2vgob_
   complexed with vx6

Details for d4af3a_

PDB Entry: 4af3, 2.75 Å

PDB Description: human aurora b kinase in complex with incenp and vx-680

PDB Compounds: (A:) aurora kinase b

SCOPe Domain Sequences for d4af3a_:

Sequence, based on SEQRES records:

>d4af3a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rhftiddfeigrplgkgkfgnvylarekkshfivalkvlfksqiekegvehqlrreieiq
ahlhhpnilrlynyfydrrriylileyaprgelykelqksctfdeqrtatimeeladalm
ychgkkvihrdikpenlllglkgelkiadfgwsvhapslrrktmcgtldylppemiegrm
hnekvdlwcigvlcyellvgnppfesashnetyrrivkvdlkfpasvptgaqdliskllr
hnpserlplaqvsahpwvransrrvlpps

Sequence, based on observed residues (ATOM records):

>d4af3a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rhftiddfeigrplgkgkfgnvylarekkshfivalkvlfksqiekegvehqlrreieiq
ahlhhpnilrlynyfydrrriylileyaprgelykelqksctfdeqrtatimeeladalm
ychgkkvihrdikpenlllglkgelkiadfgldylppemiegrmhnekvdlwcigvlcye
llvgnppfesashnetyrrivkvdlkfpasvptgaqdliskllrhnpserlplaqvsahp
wvransrrvlpps

Timeline for d4af3a_:

• d4af3a_ first appeared in SCOPe 2.02
  
• d4af3a_ appears in SCOPe 2.04
  
• d4af3a_ appears in the current release, SCOPe 2.08