SCOPe 2.02: Domain d4a4xa_: 4a4x A:

Lineage for d4a4xa_ (4a4x A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (10 species)
   not a true protein

7. Species Homo sapiens [TaxId:9606] [192729] (55 PDB entries)

8. Domain d4a4xa_: 4a4x A: [195555]
   automated match to d2w5ha_
   complexed with jup

Details for d4a4xa_

PDB Entry: 4a4x, 2.4 Å

PDB Description: NEK2-EDE bound to CCT248662

PDB Compounds: (A:) serine/threonine-protein kinase nek2

SCOPe Domain Sequences for d4a4xa_:

Sequence, based on SEQRES records:

>d4a4xa_ d.144.1.7 (A:) automated matches {Homo sapiens [TaxId: 9606]}
sraedyevlytigtgsygrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllrel
khpnivryydriidrtnttlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltl
alkechrrsdgghtvlhrdlkpanvfldgkqnvklgdfglarilnhdedfakefvgtpyy
mspeqmnrmsyneksdiwslgcllyelcalmppftafsqkelagkiregkfrripyrysd
elneiitrmlnlkdyhrpsveeilenplilehhhhhh

Sequence, based on observed residues (ATOM records):

>d4a4xa_ d.144.1.7 (A:) automated matches {Homo sapiens [TaxId: 9606]}
sraedyevlytigtgsygrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllrel
khpnivryydriidrtnttlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltl
alkechrrshrdlkpanvfldgkqnvklgdfglvgtpyymspeqmnrneksdiwslgcll
yelcalmppftafsqkelagkiregkfrripyrysdelneiitrmlnlkdyhrpsveeil
enplilehhhhhh

Timeline for d4a4xa_:

• d4a4xa_ is new in SCOPe 2.02-stable
  
• d4a4xa_ appears in SCOPe 2.03
  
• d4a4xa_ appears in the current release, SCOPe 2.08, called d4a4xa1