SCOPe 2.02: Domain d4eo6b_: 4eo6 B:

Lineage for d4eo6b_ (4eo6 B:)

1. Root: SCOPe 2.02

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (16 species)

7. Species Hepatitis c virus (isolate bk) [TaxId:11105] [195056] (1 PDB entry)

8. Domain d4eo6b_: 4eo6 B: [195057]
   automated match to d3gnwb_
   protein/RNA complex; complexed with 0s2

Details for d4eo6b_

PDB Entry: 4eo6, 1.79 Å

PDB Description: HCV NS5B polymerase inhibitors: Tri-substituted acylhydrazines as tertiary amide bioisosteres

PDB Compounds: (B:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d4eo6b_:

Sequence, based on SEQRES records:

>d4eo6b_ e.8.1.4 (B:) Viral RNA polymerase {Hepatitis c virus (isolate bk) [TaxId: 11105]}
hhsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagvqedaaslrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasqldlsgwfvagysggdiyhsls

Sequence, based on observed residues (ATOM records):

>d4eo6b_ e.8.1.4 (B:) Viral RNA polymerase {Hepatitis c virus (isolate bk) [TaxId: 11105]}
hhsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
aklqdctmlvngddlvvicesagvqedaaslrafteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasql
dlsgwfvagysggdiyhsls

Timeline for d4eo6b_:

• d4eo6b_ is new in SCOPe 2.02-stable
  
• d4eo6b_ appears in SCOPe 2.03
  
• d4eo6b_ appears in the current release, SCOPe 2.08, called d4eo6b1