SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Protein: automated matches

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2089931Superfamily c.1.23: FAD-linked oxidoreductase [51730] (2 families) (S)
    distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation
  5. 2089932Family c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 protein domains)
    automatically mapped to Pfam PF02219
  6. 2089958Protein automated matches [193645] (3 species)
    not a true protein

Species:

  1. 2089959Escherichia coli K-12 [TaxId:83333] [225710] (2 PDB entries)
    1. Domains for 3fst:
      1. 2089960Domain d3fsta_: 3fst A: [210087]
        automated match to d1b5tb_
        complexed with fad, mry, so4; mutant
      2. 2089961Domain d3fstc_: 3fst C: [210088]
        automated match to d1b5tb_
        complexed with fad, mry, so4; mutant
      3. 2089962Domain d3fste_: 3fst E: [210089]
        automated match to d1b5tb_
        complexed with fad, mry, so4; mutant
    2. Domains for 3fsu:
      1. 2089963Domain d3fsua_: 3fsu A: [210090]
        automated match to d1b5tb_
        complexed with c2f, fad, mry, so4; mutant
      2. 2089964Domain d3fsuc_: 3fsu C: [210091]
        automated match to d1b5tb_
        complexed with c2f, fad, mry, so4; mutant
      3. 2089965Domain d3fsue_: 3fsu E: [210092]
        automated match to d1b5tb_
        complexed with c2f, fad, mry, so4; mutant
  2. 2089966Thermus thermophilus HB8 [TaxId:300852] [193648] (2 PDB entries)
    1. Domains for 3apt:
      1. 2089967Domain d3apta_: 3apt A: [198905]
        automated match to d3aptb_
        complexed with act, fad
      2. 2089968Domain d3aptb_: 3apt B: [193649]
        automated match to d1v93a_
        complexed with act, fad
    2. Domains for 3apy:
      1. 2089969Domain d3apya_: 3apy A: [208294]
        automated match to d3aptb_
        complexed with cl, fad
      2. 2089970Domain d3apyb_: 3apy B: [208295]
        automated match to d3aptb_
        complexed with cl, fad
      3. 2089971Domain d3apyc_: 3apy C: [208296]
        automated match to d3aptb_
        complexed with cl, fad
      4. 2089972Domain d3apyd_: 3apy D: [208297]
        automated match to d3aptb_
        complexed with cl, fad
      5. 2089973Domain d3apye_: 3apy E: [208298]
        automated match to d3aptb_
        complexed with cl, fad
      6. 2089974Domain d3apyf_: 3apy F: [208299]
        automated match to d3aptb_
        complexed with cl, fad
      7. 2089975Domain d3apyg_: 3apy G: [208300]
        automated match to d3aptb_
        complexed with cl, fad
      8. 2089976Domain d3apyh_: 3apy H: [208301]
        automated match to d3aptb_
        complexed with cl, fad
  3. 2286894Haemophilus influenzae [TaxId:71421] [330195] (1 PDB entry)

More info for Protein automated matches from c.1.23.1: Methylenetetrahydrofolate reductase

Timeline for Protein automated matches from c.1.23.1: Methylenetetrahydrofolate reductase: