SCOPe 2.03: Domain d4bc6a_: 4bc6 A:

Lineage for d4bc6a_ (4bc6 A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (11 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (418 PDB entries)

8. Domain d4bc6a_: 4bc6 A: [193468]
   automated match to d2j7ta_
   complexed with edo, xzn

Details for d4bc6a_

PDB Entry: 4bc6, 2.2 Å

PDB Description: crystal structure of human serine threonine kinase-10 bound to novel bosutinib isoform 1, previously thought to be bosutinib

PDB Compounds: (A:) serine/threonine-protein kinase 10

SCOPe Domain Sequences for d4bc6a_:

Sequence, based on SEQRES records:

>d4bc6a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvietkseeeledyiveie
ilatcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiqvvcrqmle
alnflhskriihrdlkagnvlmtlegdirladfgvsaknlktlqkrdsfigtpywmapev
vmcetmkdtpydykadiwslgitliemaqiepphhelnpmrvllkiaksdpptlltpskw
svefrdflkialdknpetrpsaaqllehpfvssitsnkalrelvaeakaevme

Sequence, based on observed residues (ATOM records):

>d4bc6a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvietkseeeledyiveie
ilatcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiqvvcrqmle
alnflhskriihrdlkagnvlmtlegdirladfgvsaknlktlqpywmapevvmcetmkd
tpydykadiwslgitliemaqiepphhelnpmrvllkiaksdpptlltpskwsvefrdfl
kialdknpetrpsaaqllehpfvssitsnkalrelvaeakaevme

Timeline for d4bc6a_:

• d4bc6a_ first appeared in SCOPe 2.02
  
• d4bc6a_ appears in SCOPe 2.04
  
• d4bc6a_ appears in the current release, SCOPe 2.08