SCOPe 2.05: Domain d4fyoa_: 4fyo A:

Lineage for d4fyoa_ (4fyo A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase SYK [118131] (1 species)
   PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118132] (52 PDB entries)
   Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)

8. Domain d4fyoa_: 4fyo A: [193271]
   automated match to d1xbba_
   complexed with 0vf

Details for d4fyoa_

PDB Entry: 4fyo, 1.4 Å

PDB Description: crystal structure of spleen tyrosine kinase complexed with n-{(s)-1- [7-(3,4-dimethoxy-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]- pyrrolidin-3-yl}-terephthalamic acid

PDB Compounds: (A:) Tyrosine-protein kinase SYK

SCOPe Domain Sequences for d4fyoa_:

Sequence, based on SEQRES records:

>d4fyoa_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaean
vmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgm
kyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyape
cinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremy
dlmnlcwtydvenrpgfaavelrlrnyyydvvneghh

Sequence, based on observed residues (ATOM records):

>d4fyoa_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilpalkdellaeanvmqqld
npyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkylees
nfvhrdlaarnvllvtqhyakisdfglskalradenyykakwpvkwyapecinyykfssk
sdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtyd
venrpgfaavelrlrnyyydvvneghh

Timeline for d4fyoa_:

• d4fyoa_ first appeared in SCOPe 2.02
  
• d4fyoa_ appears in SCOPe 2.04
  
• d4fyoa_ is called d4fyoa1 in SCOPe 2.06
  
• d4fyoa_ appears in the current release, SCOPe 2.08, called d4fyoa1