SCOPe 2.04: Domain d4ishh_: 4ish H:

Lineage for d4ishh_ (4ish H:)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

6. Protein Coagulation factor VIIa [50550] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50551] (39 PDB entries)
   Uniprot P08709 213-466 ! Uniprot P08709 213-446

8. Domain d4ishh_: 4ish H: [192911]
   Other proteins in same PDB: d4ishl_
   automated match to d1klih_
   complexed with 1ge, ca

Details for d4ishh_

PDB Entry: 4ish, 1.82 Å

PDB Description: structure of factor viia in complex with the inhibitor bms-593214 also known as 2'-[(6r,6ar,11br)-2-carbamimidoyl-6,6a,7,11b-tetrahydro-5h-indeno[2,1-c]quinolin-6-yl]-5'-hydroxy-4'-methoxybiphenyl-4-carboxylic acid

PDB Compounds: (H:) Factor VII heavy chain

SCOPe Domain Sequences for d4ishh_:

Sequence; same for both SEQRES and ATOM records:

>d4ishh_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

Timeline for d4ishh_:

• d4ishh_ first appeared in SCOPe 2.02
  
• d4ishh_ appears in SCOPe 2.03
  
• d4ishh_ appears in SCOPe 2.05
  
• d4ishh_ appears in the current release, SCOPe 2.08