SCOPe 2.04: Domain d4d9ra_: 4d9r A:

Lineage for d4d9ra_ (4d9r A:)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

6. Protein Factor D [50563] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50564] (12 PDB entries)

8. Domain d4d9ra_: 4d9r A: [192316]
   Other proteins in same PDB: d4d9rd1, d4d9rd2, d4d9rl1, d4d9rl2
   automated match to d1bioa_
   complexed with cl

Details for d4d9ra_

PDB Entry: 4d9r, 2.42 Å

PDB Description: inhibiting alternative pathway complement activation by targeting the exosite on factor d

PDB Compounds: (A:) complement factor d

SCOPe Domain Sequences for d4d9ra_:

Sequence; same for both SEQRES and ATOM records:

>d4d9ra_ b.47.1.2 (A:) Factor D {Human (Homo sapiens) [TaxId: 9606]}
ilggreaeaharpymasvqlngahlcggvlvaeqwvlsaahcledaadgkvqvllgahsl
sqpepskrlydvlravphpdsqpdtidhdllllqlsekatlgpavrplpwqrvdrdvapg
tlcdvagwgivnhagrrpdslqhvllpvldratcnrrthhdgaiterlmcaesnrrdsck
gdsggplvcggvlegvvtsgsrvcgnrkkpgiytrvasyaawidsvla

Timeline for d4d9ra_:

• d4d9ra_ first appeared in SCOPe 2.02
  
• d4d9ra_ appears in SCOPe 2.03
  
• d4d9ra_ appears in SCOPe 2.05
  
• d4d9ra_ appears in the current release, SCOPe 2.08