SCOPe 2.06: Domain d3th2h_: 3th2 H:

Lineage for d3th2h_ (3th2 H:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Coagulation factor VIIa [50550] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50551] (88 PDB entries)
   Uniprot P08709 213-466 ! Uniprot P08709 213-446

8. Domain d3th2h_: 3th2 H: [192144]
   Other proteins in same PDB: d3th2l1, d3th2l2, d3th2l3, d3th2t1, d3th2t2
   automated match to d1klih_
   complexed with ben, bgc, ca, cl, fuc, mg, na

Details for d3th2h_

PDB Entry: 3th2, 1.72 Å

PDB Description: mg2+ is required for optimal folding of the gamma-carboxyglutamic acid (gla) domains of vitamin k-dependent clotting factors at physiological ca2+

PDB Compounds: (H:) Coagulation factor VII heavy chain

SCOPe Domain Sequences for d3th2h_:

Sequence; same for both SEQRES and ATOM records:

>d3th2h_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

Timeline for d3th2h_:

• d3th2h_ first appeared in SCOPe 2.02
  
• d3th2h_ appears in SCOPe 2.05
  
• d3th2h_ appears in SCOPe 2.07
  
• d3th2h_ appears in the current release, SCOPe 2.08